Consider Joseph. For having a call of God on his life, he was reviled by his brothers and rebuked by his parents. Eventually the brothers sold him into slavery, after very nearly killing him.
And in the end, God raised up Joseph to great leadership in Egypt. He was the catalyst for enlarging Israel in the incubator of Egypt. He was the man for the plan, but the plan was unrecognizably from God. How did Joseph not spiral in depression from such rejection from his loved ones?